Four new C₁₀-polyacetylene glycosides from the rhizomes of Atractylodes lancea

Abstract

An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C₁₀-type polyacetylene glycosides (1−4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2−4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds 2 and 3 showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM.

Keywords:

• Atractylodes lancea
• polyacetylene glycoside
• hepatoprotective activity
• anti-inflammatory effect