Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity

Sheng LinDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China

Peng FuDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai200433, China

Tao ChenState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou510120, China

Ji YeDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China

Xian-Wen YangDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China

Wei-Dong ZhangDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, ChinaCorrespondence[email protected]

Abstract

Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MSⁿ. All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3 M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC₅₀ values of 2.8–8.3 μM.

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Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity

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Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity

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