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Articles

Three new drimane sesquiterpenoids from cultures of the fungus Penicillium sp.

, , , , , & show all
Pages 780-785 | Received 18 May 2016, Accepted 15 Nov 2016, Published online: 28 Nov 2016
 

Abstract

Three new drimane sesquiterpenoids, 12-hydroxyalbrassitriol (1), drim-8(12)-en-6β,7α, 9α,11-tetraol (2), and drim-68(12)-dien-9α,11-diol (3), along with one known analog albrassitriol (4), were isolated from cultures of the tin mine tailings-associated fungus Penicillium sp. The new structures were determined on the basis of extensive spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines.

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