Cytotoxic diterpenoids from Pteris ensiformis

Abstract

Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2–6) and three known sesquiterpenes (7–9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1–9) were evaluated for their antitumor activity against three cancer cell lines.

Keywords:

• Pteris ensiformi
• Pteridaceae
• ent-kaurane diterpenoid
• cytotoxicity
• ent-kaurane-6β
• 16α-diol-3-one

Acknowledgments

Thanks to the support from College of Life Science, Dalian Nationalities University.