Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp. Xy24

Abstract

A new steroid glucoside (1), along with nine known steroids (2–10) and four known sorbicillinoids (11–14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5–7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC₅₀ values ranging 1.9–9.3 μM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 μM, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC₅₀ values of 11.1 and 17.7 μM, respectively.

Keywords:

• Steroids
• sorbicillinoids
• Trichoderma sp. Xy24
• anti-HIV activity
• anti-inflammatory activity
• cytotoxicity