Three new anthraquinones from the twigs of Cassia fistula and their bioactivities

Min ZhouKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming650000, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Huan-Huan XingKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Yan YangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Yue-De WangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Kun ZhouKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Wei DongKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Gan-Peng LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, China

Wei-Yao HuTechnology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming650000, China

Qiang LiuTechnology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming650000, China

Xue-Mei LiTechnology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming650000, ChinaCorrespondence[email protected]

Qiu-Fen HuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650031, China;School of Ethnic Medicine, Yunnan Minzu University, Kunming650031, ChinaCorrespondence[email protected]

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Abstract

Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC₅₀ values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.

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Three new anthraquinones from the twigs of Cassia fistula and their bioactivities

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Three new anthraquinones from the twigs of Cassia fistula and their bioactivities

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