Biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9

Qi DongMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Ye YuanMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Yue ZhouMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Yi-Xin ZhangMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Jian-Peng ZhangDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Hao-Bing YuMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Bing-Hua JiaoMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, China

Xiao-Yu LiuMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, ChinaCorrespondence[email protected]

Xiao-Ling LuMarine Biopharmaceutical Institute, Second Military Medical University, Shanghai200433, China;Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai200433, ChinaCorrespondence[email protected]

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Abstract

The biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9 yielded three new products, lecaniside A (1), lecaniside B (2), and lecaniside C (3). The chemical structures of these metabolites were elucidated based on extensive spectral data, including 2D NMR and HRMS. The hydrogenation, dealkylation, glycosylation, and O-methylation reactions of these metabolites were observed in the present study. In the in vitro assays, compound 1 displayed a little PTP1B inhibitory activity.

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Acknowledgments

Thank you for Professor Bo Chen of Polar Research Institute of China to support the fungus Lecanicillium attenuatum W-1-9.

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Biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9

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Biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9

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