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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 10
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Two new ent-kaurane diterpenes from the stems of Eurya chinensis

Jia-Ling SongProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing100049, China
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Yao YuanProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing100049, China
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Ling-Hui NieCollege of Traditional Chinese Medicine, Southern Medical University, Guangzhou510515, China
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Bai-Lin LiProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing100049, China
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Xu-Bing QinProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing100049, China
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Yan LiProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, China;College of Life Sciences, University of Chinese Academy of Sciences, Beijing100049, China
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Jie-Wei WuProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-0555-6086
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Sheng-Xiang QiuProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou510650, ChinaCorrespondence[email protected]
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Pages 962-968 | Received 22 Mar 2017, Accepted 25 Aug 2017, Published online: 11 Sep 2017
 
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Abstract

Two new ent-kaurane diterpenes (1–2), together with five known analogs, were isolated from the stems of Eurya chinensis. The structures of new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound 3 exhibited noticeable anti-inflammatory activity as denoted by inhibiting LPS-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 7.82 μM. Compound 4 showed potent cytotoxic activity against human cancer cell lines NCI-H46, HepG2 and SW480 with IC50 values ranging from 7.45 to 8.54 μM.

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Related Research Data

Two new ent-kaurane diterpenes from the stems of Eurya chinensis
Source: Figshare
Two new ent-kaurane diterpenes from the stems of Eurya chinensis
Source: Figshare

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