The chemical constituents from Urtica fissa leaves

Abstract

A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4–19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC₅₀ values less than 4.0 μM.

Keywords:

• Urticaceae
• Urtica fissa
• secolignan
• ceramide
• anti-inflammation

Acknowledgements

The authors are really grateful to Dr. Bona Dai of the Instrumental Analysis Center of Shanghai Jiao Tong University, for the measurements of NMR.