Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression

Abstract

Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.

Keywords:

• Corydaline
• enterovirus 71
• MAPK
• COX-2

Acknowledgments

We are grateful to Dr Qi Jin, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College (Beijing, China) for providing EV71 strain SHZH98. We are also grateful to Dr Zhaohua Zhong, Department of Microbiology, Harbin Medical University for providing plasmids.