Synthesis and antitumor activities of sinomenine derivatives on rings A and C

Abstract

A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities.

Keywords:

• Sinomenine
• modification
• derivatives
• esterification
• antitumor

Acknowledgment

Special thanks are given to Mr Wang and Mr Du for technical support in bioassays and Mr He for assistance with recording 2D NMR spectra.