116
Views
2
CrossRef citations to date
0
Altmetric
Articles

Ergostane steroids from the ethanol extract of Dysoxylum mollissimum

, , , &
Pages 103-108 | Received 14 Jul 2017, Accepted 11 Oct 2017, Published online: 30 Oct 2017
 

Abstract

Three new ergostane steroids, 7α-acetoxyl-ergosta-5,24(28)-diene-3β,4β,20S-triol (1), 7α-acetoxyl-ergosta-5,24(28)-diene-3β,4β-diol (2), and 7α-acetoxyl-ergosta-5,24(28)-3β-ol (3) were isolated from the ethanol extract of stem bark of Dysoxylum mollissimum BI. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the isolated steroids were in vitro evaluated for their anti-inflammatory activity against COX-1 and COX-2. As a result, steroids 13 exhibited modest selective inhibition for COX-1 (>60%).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.