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Two new illudane sesquiterpenoids, craterellins D and E (1 and 2), and one new menthane monoterpene, 4-hydroxy-4-isopropenyl-cyclohexanemethanol acetate (3), were isolated from cultures of Craterellus cornucopioides. Structures of 1–3 were elucidated on the basis of extensive spectroscopic analysis. Their cytotoxic activities on five tumor cell lines were evaluated.
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