The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model

Lei XinResearch Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China;Pharmacy Department, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai200032, China

Xiao-Hui LiuResearch Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China

Jun YangPharmacy Department, Xiangshan Hospital of Traditional Chinese Medicine, Shanghai200020, China

Hong-Yi ShenResearch Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China

Guang JiInstitute of Digestive Diseases, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai200032, China

Xiu-Feng ShiPharmacy Department, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai200032, ChinaCorrespondence[email protected]

Yan XieResearch Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China;Institute of Digestive Diseases, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai200032, ChinaCorrespondence[email protected]

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Abstract

The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and intestinal flora could participate in their absorption processes. The absorption mechanisms of IS, QU, and KA in TFH were involved in both passive diffusion and active transport, and the mediation of efflux transporter multidrug resistance-associated proteins (MRPs) should not be neglected.

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The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model

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The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model

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