Two new steroidal saponins from the roots of Cynanchum limprichtii

Jia-Chuan LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;College of Basic Science, Jinzhou Medical University, Jinzhou121001, China

Li-Li YuCollege of Basic Science, Jinzhou Medical University, Jinzhou121001, China

Ming-Xu TangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Xiao-Jie LuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Dan ZhaoSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Hai-Feng WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Gang ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China

Guang-Yue SuSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

Yue-Hu PeiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]

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Abstract

As a part of our continuing research for bioactive constituents from Cynanchum limprichtii Schltr., two new C₂₁ steroidal glycosides limproside A (1) and limproside B (2) were isolated from the roots of Cynanchum limprichtii. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The cytotoxicity of two compounds against two selected human cancer cell lines was assayed.

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Two new steroidal saponins from the roots of Cynanchum limprichtii

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Two new steroidal saponins from the roots of Cynanchum limprichtii

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