Xylarodons A and B, new hexaketides from the endophytic fungus Xylaria sp. SC1440

Abstract

Two new hexaketides, xylarodons B (1) and C (2), were isolated from solid cultures of the endophytic fungus Xylaria sp. SC1440. The structures of these compounds were elucidated on the basis of detailed 1D, 2D NMR, and HRESIMS analysis. Their absolute configurations were established by experimental and TDDFT calculated ECD spectra. The isolated compounds were evaluated for cytotoxic and tyrosinase inhibitory activity.

Keywords:

• Hexaketides
• endophytic fungus
• Xylaria sp
• secondary metabolites

Acknowledgments

We gratefully acknowledge support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, and thank Ai-Jun Sun and Yun Zhang, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for the measurement of HRESIMS.