Three new tetralol analogs from soil-derived fungus Myrothecium verrucaria with anti-inflammatory activity

Abstract

Three new tetralol analogs, myrochromanols A-C (1–3), together with 11 known trichothecenes (4–14), were isolated from a soil fungus Myrothecium verrucaria HL-P-1. The structures of the three new compounds were elucidated by extensive spectroscopic analysis including HRESIMS, NMR, and ECD calculation. All of the new compounds were tested for their anti-inflammatory activity and cytotoxicity. Compounds 1 and 3 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells with IC₅₀ values of 26.04 and 25.80 μM, respectively.

Three new tetralol analogs were isolated from a soil fungus Myrothecium verrucaria HL-P-1. All of them were tested for their anti-inflammatory and cytotoxicity activity.

Keywords:

• Tetralol analogs
• Myrothecium verrucaria
• anti-inflammation
• cytotoxicity

Acknowledgments

We thanked the Supercomputing Environment of Chinese Academy of Sciences for supplying ECD environment.