New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii

Thi Quynh Do Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Bich Ngan Truong Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Huong Doan Thi Mai Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, VietnamCorrespondence[email protected]

Thuy Linh Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Van Hung Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Hai Dang Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Tien Dat Nguyen Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam; Center for Research and Technology Transfer, VAST , Hanoi100000, Vietnam

The Cuong Nguyen Institute of Ecology and Biological Resources, VAST , Hanoi100000, Vietnam

Trieu Vung Luong Department of Agriculture and Rural Development of Ha Giang , Ha Giang310000, Vietnam

Loc Thang Giang Pho Bang Centre for Plant and Animal Varieties , Ha Giang310000, Vietnam

Van Minh Chau Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, Vietnam

Van Cuong Pham Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi100000, VietnamCorrespondence[email protected]

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Abstract

Four new compounds N-salicyl-3-hydroxyanthranilic acid methyl ester (1), N-(2′-dehydroxysalicyl)-3-hydroxyanthranilic acid methyl ester (2), methyl-4-β-D-allopyranosyl-ferulate (3), and methyl-4-β-D-gulopyranosyl-cinnamate (4), along with six known compounds (5–10), were isolated from the roots of Aconitum carmichelii Debx. Their structures were elucidated on the basis of spectral data analysis, including 1D, 2D-NMR, and HR-ESI-MS. Compounds 1 and 2 showed the inhibition of nitric oxide (NO) production with IC₅₀ values of 9.13 and 19.94 μM, respectively.

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New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii

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New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii

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