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Articles

Synthesis and antifungal evaluation of PCA amide analogues

, , , , &
Pages 587-596 | Received 18 Dec 2017, Accepted 03 Apr 2018, Published online: 18 Apr 2018
 

Abstract

To improve the physical and chemical properties of phenazine-1-carboxylic acid (PCA) and find higher antifungal compounds, a series of PCA amide analogues were designed and synthesized and their structures were confirmed by 1H NMR, HRMS, and X-ray. Most compounds showed some antifungal activities in vitro. Particularly, compound 3d exhibited inhibition effect against Pyriculariaoryzac Cavgra with EC50 value of 28.7 μM and compound 3q exhibited effect against Rhizoctonia solani with EC50 value of 24.5 μM, more potently active than that of the positive control PCA with its EC50 values of 37.3 μM (Pyriculariaoryzac Cavgra) and 33.2 μM (Rhizoctonia solani), respectively.

Acknowledgments

We thank the Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University for HRMS and 1H NMR spectra.

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