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Articles

Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides

ORCID Icon, , &
Pages 619-626 | Received 19 Nov 2017, Accepted 08 Apr 2018, Published online: 28 May 2018
 

Abstract

Three new acylphloroglucinols (13) and four known biosynthetically related analogs (47) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 17 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer’s diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure–activity relationship was also discussed.

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