2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11

Ying-Ying Si School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Ming-Xu Tang School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Shuang Lin School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Gang Chen School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Hui-Ming Hua School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Jiao Bai School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China

Yu-Bo Wang School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, China; School of Pharmacy, Jinzhou Medical University , Jinzhou121001, China

Hai-Feng Wang School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, ChinaCorrespondence[email protected]

Yue-Hu Pei School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang110016, ChinaCorrespondence[email protected]

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Abstract

A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1), together with six known compounds (2–7), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was determined by the experimental and calculated ECD data. In addition, the cytotoxic activities against three human cancer cell lines (HL-60, THP-1, and PC-3) were evaluated.

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2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11

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2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11

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