Trichodermatides E and F from fungus Trichoderma applanatum

Abstract

Two new polyketide derivatives, trichodermatides E (1) and F (2), are unprecedented examples of a polyketide with 6/6/6/6 tetracyclic skeleton, together with five known analogs koninginin B (3), koninginin D (4), 7-O-methylkoninginin D (5), koninginins E and F (6–7), were isolated from the plant endophytic fungus Trichoderma applanatum. The structures of these two compounds were determined by NMR data and HR-ESI-MS analysis. The putative biosynthesis of compounds 1–7 was presented.

Keywords:

• Trichoderma applanatum
• trichodermatides
• antifungal
• polyketides

Acknowledgment

We thank Professor Wenhan Lin for the helpful discussion on structural elucidation. We thank Drs. Jinwei Ren and Wenzhao Wang (Institute of Microbiology, CAS) for MS and NMR data collection. W.B.Y. is a scholar of “the 100 Talents Project” of CAS.