(±) Cochlearoids N–P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities

Abstract

Three pairs of meroterpenoids (±) cochlearoids N–P (1–3) were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by spectroscopic techniques. All the isolated compounds were tested for their inhibitory activities toward BRD4, human cancer cells, and micro-organisms. The results show that the enantiomers of (±)-1 are BRD4 inhibitors, (−)-1 and (+)-3 are cytotoxic against human cancer cells (K562) with IC₅₀ values of 7.68 and 6.68 μM, respectively. Besides compounds (±)-2 and (±)-3 exhibit potent inhibitory activity against Staphylococcus aureus with IC₅₀ values in the range of 5.43–17.99 μM.

Keywords:

• Ganoderma cochlear
• meroterpenoids
• BRD4
• cytotoxic activity
• antibacterial activity