Alkaloids from Melodinus henryi with anti-inflammatory activity

Jin-Qian YuShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, ChinaCorrespondence[email protected]

Xiao-Wei SunSchool of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan250014, China

Zhi-Wei WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, China

Lei FangCollege of Biological Sciences and Technology, University of Jinan, Jinan250022, China

Xiao WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan250014, China;School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan250014, ChinaCorrespondence[email protected]

Abstract

One new quinolinic scandine-type monoterpeniod alkaloid, 3-oxo-scandine (1), as well as seven known ones (2–8), was isolated from the roots of Melodinus henryi. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were prepared and evaluated for their anti-inflammatory activities by measuring the inhibitory activity of nitric oxide (NO) in vitro in RAW 264.7 mouse peritoneal macrophages. Compounds 6 and 7 showed significant activities with IC₅₀ values of 8.54 and 5.19 μM, respectively.

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Alkaloids from Melodinus henryi with anti-inflammatory activity

Information for

Open access

Opportunities

Help and information

Alkaloids from Melodinus henryi with anti-inflammatory activity

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature