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Original Articles

Chemical constituents from the culture of the fungus Hericium alpestre

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Pages 735-741 | Received 19 Nov 2017, Accepted 29 May 2018, Published online: 17 Jul 2018
 

Abstract

Two new compounds herialpins A–B (12), along with eleven known compounds, were isolated from the culture of fungus Hericium alpestre. The structures were elucidated by 1D and 2D NMR data, ESI-MS and X-ray crystallographic analysis. Compounds 12 were assayed for their cytotoxicity against three tumor cell lines compared with the known compound 3. Compounds 1 and 2 were found with modest activity, while compound 3 exhibits stronger selective inhibitory activity against A549 and HT-29 cells with IC50 values of 15.1 and 20.1 μmol/L, respectively. The pyrano[3,4-g]chromene-4,6-dione moiety in compound 3 should be responsible for the stronger selective inhibitory activity.

Acknowledgments

We are grateful to key laboratory of Chemical Biology of Shandong University for providing Hericium alpestre.

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