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Abstract
The phytochemical investigation of the roots of Daphne genkwa yielded six secondary metabolites, including a new flavanol derivative, (2R, 3S)-5,7,4′-trihydroxy-8-methoxycarbonylflavanol (1), and five known compounds (2–6). The molecular structures of the isolated constituents were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, the cytotoxic activity of 1 and 2 against A549, HL-60, SMMC-7721, MCF-7, and SW480 cell lines was also described.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was financially supported by the National Natural Science Foundation of China (No. 81303202) and the Research and Development Project of the Colleges in Shandong Province (No. J17KA251).