Plasma pharmacokinetics of isorhapontigenin, a novel derivative of stilbenes, in mice by LC-MS/MS method

Abstract

Isorhapontigenin (ISO), a novel derivative of stilbene compound, possessess good pharmacological activities such as antiviral, antioxidant, and anticancer. The purpose of this study is to investigate the pharmacokinetic of ISO in mice plasma, after oral administration of three doses (40, 80, and 160 mg/kg). Isorhapontigenin was detected by liquid chromatography–tandem mass spectrometry (LC-MS/MS), and a reliable LC-MS/MS assay for ISO in mice plasma was developed. The method was linear over a concentration range of 5–2000 ng/ml, and the lower limit of quantification was 5 ng/ml. The results indicated that there was a linear relationship between AUC_(0–t), AUC_(0–∞), and C_max of ISO and dosages. ISO underwent quick absorption and elimination in mice.

Keywords:

• Isorhapontigenin
• pharmacokinetics
• mice plasma
• LC-MS/MS
• quick absorption

Acknowledgments

The authors acknowledge Ms. Yin, Ms. Mao, and Ms. Zhang for their technical assistance.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Fundamental Research Funds for the Central Universities, China (2014CX16).