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Abstract
Nine ursane-type triterpenoids including three new ones 2α, 19α-dihydroxyurs-3-O-acetyltormentic acid (1), 1α, 2α, 3α, 20β-tetrahydroxyurs -13(18)-en-28-oic acid (2), and 2α, 3α, 20β, 24-tetrahydroxyurs-13(18)-en-28-oic acid (3) were isolated from the roots of Rosa multiflora. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and IR spectroscopic analyses data. All the isolates were evaluated for their anti-inflammatory activity in vitro and the results showed that compounds 1–9 displayed moderate inhibitory activity with IC50 values ranging from 24.7 to 86.2 μM compared with the postitive control Amino guanidine (IC50 4.3 μM).
Additional information
Funding
The work was supported financially by the National Natural Science Foundation of China (Grant No. 81703684), Natural Science Foundation of Heilongjiang Province (No. H2015037), Post-doctoral initial fund of Heilongjiang Province; University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(No. UNPYSCT-2017215; UNPYSCT-2017219), Heilongjiang University of Chinese Medicine Doctoral Innovation Foundation (No. 2014bs05), Application Technology Research and Development Projects of Harbin Technology Bureau (No. 2014RFQXJ149), Innovative Talents Funding of Heilongjiang University of Chinese Medicine, Heilongjiang Postdoctoral Scientific Research Developmental Fund (NO:LBH-Q16210), and Heilongjiang University of Chinese Medicine Doctoral Innovation Foundation (No: 2013bs04).