Triterpenoids with α-glucosidase inhibitory activity from Artemisia argyi

Abstract

Two new nordammarane-type triterpenoids, 3β-acetoxy-20-oxo-21-nordammaran-23-carboxylic acid methyl ester (1) and 3β-acetoxy-17β-dammaranic acid (2), along with two known cycloartane-type triterpenoids (3–4), were isolated from the petroleum ether-soluble extract of Artemisia argyi. Their structures were elucidated based on 1D and 2D NMR spectroscopic data analysis. All compounds were evaluated for their α-glucosidase inhibitory activity in vitro. Compounds 1–4 exhibited significant inhibitory effects on α-glucosidase with IC₅₀ values ranging from 38.34 ± 0.23 to 105.54 ± 0.33 μM.

Graphical Abstract

Keywords:

• Artemisia argyi
• compositae
• triterpenoids
• α-glucosidase inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This research was financially supported by grants from the National Natural Science Foundation of China [grant number 31400305 and 81773898] and the Project for Youth Backbone Teachers in the University of Henan Province [grant number 2015GGJS-130].

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.