Two new compounds from Streptomyces sp. HS-NF-813

Abstract

Two new derivatives of cytotoxic substance BE-52211, designed as BE-52211D (1) and BE-52211E (2), were isolated from the fermentation broth of the strain Streptomyces sp. HS-NF-813. Their structures were determined by 1D and 2D NMR techniques, ESI-MS and comparison with data from the literature. The absolute stereochemistry of 1 was elucidated by NMR data of the Mosher ester derivatives. Compounds 1 and 2 showed moderate cytotoxic activity against three human tumor cell lines.

Graphical Abstract

Keywords:

• Streptomyces sp. HS-NF-813
• BE-52211D
• BE-52211E
• modified Mosher’s method
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported in part by grants from the National Key Research and Development Plan (no. 2017YFD0201606).