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Abstract
A new xanthyletin-type coumarin, neopeucedalactone (1), was isolated from the roots of Peucedanum praeruptorum Dunn. Its chemical structure was elucidated based on extensive spectroscopic interpretation. The absolute configurations of xanthyletin-type coumarin were determined by comparing experimental and calculated ECD spectra for the first time. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60, THP-1 cell lines, and human prostate cancer PC-3 cell lines, with IC50 values of 9.97, 27.80, and 48.68 µM, respectively.
Acknowledgments
The authors are grateful to Mr. Jingchao Liu and Mr. Zishuang Liu (Analytical Testing Center, Northeast University, Shenyang, China) for their measurements of the NMR data.
Disclosure statement
No potential conflict of interests was reported by the authors.
Funding
Financially support of this investigation by Scientific Research Foundation of Shenyang Agricultural University (Grant No. 880415026) is gratefully acknowledged.
