http://orcid.org/0000-0003-3999-7170
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Abstract
One new aspidosperma-type alkaloid, melotenine A (1), together with five known ones (2–6), was isolated from the leaves of Melodinus axillaris. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical ECD calculation. The isolated aspidosperma-type alkaloids were evaluated for their cytotoxicity against four human cancer cell lines and melotenine A showed significant cytotoxicity against all cells with IC50 values ranging from 0.6 to 1.5 μM.
Disclosure statement
The authors declare that there are no conflicts of interest.
Additional information
Funding
This work was financially supported by Natural Science Foundation of China (21772065, 81673527), Postdoctoral Science Foundation of China (2017M622268), Shandong Provincial Natural Science Foundation (ZR2017MH019, JQ201721), Shandong Provincial Key Research Project (2017GSF19115, 2018GSF118158), Shandong Talents Team Cultivation Plan of University Preponderant Discipline (No. 10027), and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) (CMEMR2016- B07).
