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Abstract
Phytochemical investigation of Urtica fissa seed led to the isolation of a new secolignan (1) and a new glycoalkaloid (2), together with 16 known compounds (3−18). The subsequent active evaluation indicated that two lignans (1, 12), two ceramides (3, 4), and the glycoalkaloid (2) possessed the significant cytotoxicity. They could obviously inhibit the proliferation of tumor cells HeLa and CCRF-CEM cells, with IC50 values as low as 1.5 μM.
Acknowledgment
The authors are really grateful to Dr. Bona Dai and Dr. Juan Gui of the Instrumental Analysis Center of Shanghai Jiao Tong University, for the measurements of NMR and MS, respectively.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was financially supported by National Natural Science Foundation of China (No. 81374067) and Shanghai Municipal Commission of Health and Family Planning (2018ZY002).