269
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Bioactive phenolic acid-substituted glycoses and glycosides from rhizomes of Cibotium barometz

, , , , , & show all
Pages 947-953 | Received 06 Nov 2018, Accepted 20 Dec 2018, Published online: 29 Jan 2019
 

Abstract

Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4–12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1–3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated for the hepatoprotective activities against APAP-induced HepG2 cell damage. Compounds 1, 47, 10 exhibited significant hepatoprotective activities, even more strongly than positive control, bicycol. In addition, compounds 1 and 9 could reduce PC12 cell death induced by serum deprivation.

Acknowledgments

The authors greatly thank Prof. Xiaoguang Chen (cytotoxicity), Prof. Naihong Chen (neuroprotection), Prof Fei Ye (XOD), and Prof Qi Hou (anti-inflammation) for conducting the bioassay experiments.

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Funding

This work was financially supported by the CAMS Innovation Fund for Medical Sciences (CIFMS) No. 2016-I2M-3-011.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.