Two new isoflavones from the seeds of Psoralea corylifolia with diacylglycerol acyltransferase inhibitory activity

Abstract

Two new compounds 7-hydroxy-4'-methoxy-3'-(7''-hydroxy-3'',7''-dimethyl-octa-2'',5''-dienyl)-isoflavone (1) and 7-hydroxy-4'-methoxy-3'-(6''-hydroxy-3'',7''-dimethyl-octa-2'',7''-dienyl)-isoflavone (2), together with five known compounds (3–7), were isolated from EtOAc-soluble extract of the seeds of Psoralea corylifolia. Their structures were elucidated on the basis of detailed spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against diacylglycerol acyltransferase (DGAT). And compounds 1–7 displayed significant inhibitory activity on DGAT1 with IC₅₀ values ranging from 51.2 ± 1.1 to 116.4 ± 1.3 μM.

Graphical Abstract

Keywords:

• Leguminosae
• Psoralea corylifolia
• isoflavones
• diabetes
• DGAT

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

Figure 1. Key HMBC correlations of compounds 1 and 2.

Figure 2. Structures of compounds 1–3.

This research was financially supported by the Project Sponsored by the Scientific and Technological Developing Scheme of The First People’s Hospital of Jining (201501724JC).