![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Twelve dihydrostilbenes (including five new analogues) were prepared by the Witting-Hornor reaction from appropriate aromatic aldehydes and phosphonate esters, followed by hydrogenation in five steps. The in vitro inhibition activity against human neutrophil elastase (HNE) of these dihydrostilbenes was evaluated, and three 1,2-dihydroxylated dihydrostilbenes (6b, 6j, and 6l) exhibited stronger inhibitory activity against HNE than other analogues.
Graphical Abstract
Acknowledgments
The authors thank Prof. Yiming Li and Dr. Li Feng at Shanghai University of Traditional Chinese Medicine for providing HNE activity tests.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This investigation was financially supported by a grant (Nos 31260085 and 21861043) from the Natural Science Foundation of China, the Key Laboratory (No. 2016-5), and Science and Technology Innovation Team of Higher Education (No. 2014-6) in Yunnan, China.
