Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways

Abstract

The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.

Graphical Abstract

Keywords:

• Sulforaphane
• liver failure
• inflammation
• toll-like receptor
• lipopolysaccharide

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [grant number HI15C0001] and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) [grant number 2018R1A5A2025272].