Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from Aquilaria sinensis

Abstract

Two new compounds 6,7-dimethoxy-2-[2-(2′-hydroxyphenyl)ethyl]chromone (1) and 6,7-dimethoxy-2-[2-(4′-hydroxyphenyl)ethenyl]chromone (2), together with ten known 2-(2-phenylethyl)chromones (3–12) were isolated from the resinous wood of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by detailed IR, MS, NMR spectroscopic analyses, and comparison with reported. The absolute configuration of 3 was confirmed by Cu Kα X-ray crystallographic experiment, and the X-ray crystallographic data of 3 were firstly reported. Compounds 2, 8, 10, and 11 exhibited strong ABTS^•+ radical scavenging activity, with IC₅₀ values of 12.3, 16.5, 12.1, and 34.7 μM, respectively.

Keywords:

• Aquilaria sinensis
• Chinese eaglewood
• 2-(2-phenylethyl)chromones
• ABTS^•+ radical scavenging activity
• antioxidant activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Natural Science Foundations of China (81222053) and the Shanghai Science and Technology Development Foundation (15DZ0502602).