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Original Articles

Three new isoquinoline alkaloids from the whole plants of Thalictrum tenue with cytotoxic activities

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Pages 618-625 | Received 23 Feb 2019, Accepted 15 Apr 2019, Published online: 03 May 2019
 

Abstract

Three new isoquinoline alkaloids, including two aporphines (1 and 2) and one oxoaporphine (3), were isolated from the 90% EtOH extract of the whole plants of Thalictrum tenue Franch. The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry, respectively. The isolated alkaloids were tested in vitro for cytotoxic activity against six esophageal carcinoma cell lines. Consequently, alkaloids 1-3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC50 values less than 20 μM.

Disclosure statement

No potential conflict of interest was reported by the authors.

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