Antioxidant epoxydon and benzolactone derivatives from the insect-associated fungus Phoma sp.

Abstract

One new epoxydon ester (1) and a new benzolactone derivative (2), along with four known compounds (3−6), were isolated from the insect-associated fungus Phoma sp. Their structures were confirmed by extensive MS and NMR spectroscopic analysis and their absolute configurations were determined by a combination of modified Mosher method and Mo₂(OCOCH₃)₄-induced electronic circular dichroism (ECD) experiments. Compounds 1 and 5 were revealed to have potent antioxidant activities, which were approximate to the potency of the positive control trolox. In addition, 1 also exhibited moderate cytotoxic effect against human MGC-803 tumor cell line.

Keywords:

• Phoma sp.
• epoxydon derivative
• benzolactone
• antioxidant activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China [U1604176], the Science and Technology Planning Project of He'nan Province [182102310651], and the Ph.D. Programs Foundation of Zhengzhou University of Light Industry [13501050056].