Synthesis and anti-tumor activity of derivatives of ring A of asiatic acid

Abstract

Based on the simulation of the docking of survivin protein with known small molecule inhibitors, the active groups which can bind to target proteins were analyzed by the techniques of computer-aided drug design (CADD). These active groups were introduced into the A-ring of asiatic acid and their C-28 sites were reconstructed simultaneously. Ten asiatic acid derivatives were designed and synthesized, and their structures were confirmed by MS and NMR. The inhibitory activities of the asiatic acid derivatives against HepG2 and SGC7901 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The results showed that compounds I₆ and II₄ exhibited more potent cytotoxicity than the positive control drug gefitinib, which was comparable to that of adriamycin.

Keywords:

• Asiatic acid derivatives
• molecular docking
• synthesized
• anti-tumor activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This research was financially supported by National Natural Science Foundation of China[21372156]; the Liaoning University Innovation Team Support Project [LT2017009]; the Liaoning Province key R & D project [2019JH2 /10300034]; and the Key projects of Shenyang University of Chemical Technology [LDB2019001].