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A new bile acid from the traditional chinese medicine shedan

Yan Yuana Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information

Qiu-Yan Wanga Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information

Jie Zhanga Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information

Jing Nieb Hubei Institute for Drug Control, Wuhan430075, ChinaView further author information

Cheng-Gao Zhoua Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information

Wen-Qin Yia Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information

Luo-Sheng Wana Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaCorrespondence[email protected]
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Jia-Chun Chena Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaCorrespondence[email protected]
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Abstract

A new bile acid tauro-16β-hydroxy-12α-sulfate-5β-cholenoic acid (1), along with six known ones (2–7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 μM) with inhibitory rate of 69.7%.

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No competing financial interest was reported by the authors.

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This work was financially supported by the National Natural Science Foundation of China [grant number 31870330, 81373917 and 81773869].

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A new bile acid from the traditional chinese medicine shedan

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A new bile acid from the traditional chinese medicine shedan

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