Abstract
Two new polyoxy steroidal glycosides, named as 11- O-α-acetyl-12-O-β-tigloyl- 3β,14β-dihydroxy-pregn-5-en-20-one-3-O-β-D-oleadropyranosyl-(1→4)-β-D-6-deoxy-3-O-methyl-allopyanoside (1) and 11- O-α-acetyl -12-O-β-benzoate-3β, 14β-dihydroxy-pregn-5-en- 20-one-3-O-β-D-oleadropyranosyl-(1→4)-β-D-6-deoxy-3-O-methyl-allopyanoside (2) were isolated from the roots of Dregea sinensis Hemsl. Their structures were elucidated by various spectroscopic techniques including UV, IR, HRESIMS, 1 D and 2 D NMR. All the two compounds were tested for their cytotoxic activity in vitro, and the result showed that compounds 1-2 displayed moderated cytotoxic activity against HL-60 cell line with IC50 values of 18.4 μM and 23.9 μM, respectively.
Disclosure statement
No potential conflict of interest was reported by the authors.