Two new polyoxy steroidal glycosides from the roots of Dregea sinensis Hemsl

Abstract

Two new polyoxy steroidal glycosides, named as 11- O-α-acetyl-12-O-β-tigloyl- 3β,14β-dihydroxy-pregn-5-en-20-one-3-O-β-D-oleadropyranosyl-(1→4)-β-D-6-deoxy-3-O-methyl-allopyanoside (1) and 11- O-α-acetyl -12-O-β-benzoate-3β, 14β-dihydroxy-pregn-5-en- 20-one-3-O-β-D-oleadropyranosyl-(1→4)-β-D-6-deoxy-3-O-methyl-allopyanoside (2) were isolated from the roots of Dregea sinensis Hemsl. Their structures were elucidated by various spectroscopic techniques including UV, IR, HRESIMS, 1 D and 2 D NMR. All the two compounds were tested for their cytotoxic activity in vitro, and the result showed that compounds 1-2 displayed moderated cytotoxic activity against HL-60 cell line with IC₅₀ values of 18.4 μM and 23.9 μM, respectively.

Keywords:

• Asclepiadaceae
• polyoxy steroidal glycosides
• Dregea sinensis
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81403088), Quality Guarantee System of Chinese Herbal Medicines (No. 201507002), Project funded Tujia Medicine Research Center in Hunan (No. 20172001), and Construct Program of the Key Discipline in Hunan Province (No. JSU0713).