Matteuinterins A–C, three new glycosides from the rhizomes of Matteuccia intermedia

Abstract

Phytochemical investigation on the rhizomes of Matteuccia intermedia C.Chr. led to the isolation of three new compounds, named matteuinterins A–C (1–3), together with seven known compounds (4–10). Their structures were elucidated by extensive NMR analyses and chemical derivatization. Compounds 5–10 were evaluated for their anti-inflammatory activities on PGE₂ release in LPS-stimulated RAW 264.7 murine macrophages. Compounds 5 and 10 exhibited inhibitory effect on PGE₂ production in LPS-activated murine macrophages with IC₅₀ values of 17.8 ± 1.5 and 30.3 ± 2.1 μM, respectively.

Keywords:

• Onocleaceae
• Matteuccia intermedia
• sesquiterpenoid glycoside
• chromone glycoside
• phenolic glycoside
• inhibitory effect on PGE₂ production

Acknowledgments

The authors are grateful to Prof. Hao Zhang in West China School of Pharmacy, Sichuan University, China, for the botanical identification. Thanks are also given to Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University for the HRESIMS measurement.

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.