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Original Articles

New metabolites from a Mariana Trench-derived actinomycete Nocardiopsis sp. HDN 17-237

, , , , , , & show all
Pages 1031-1036 | Received 14 May 2019, Accepted 13 Oct 2019, Published online: 22 Nov 2019
 

Abstract

One new β,γ-butenoate derivative phenylbutenote (1), and one new α-pyrone nocapyrone T (2) were isolated from the deep-sea derived actinomycete Nocardiopsis sp. HDN 17-237. Their structures were elucidated by extensive HRMS, IR and NMR analyses. Among them, compound 1 is the first microbial natural products bearing a rare β,γ-butenoate moiety, and compound 2 is the first α-pyrone isolated from strain of Mariana Trench. Compounds 1 and 2 were tested for antioxidant and antibacterial activities, while none of them showed significant activity.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by the National Key R&D Program of China (2018YFC0310800), the Fundamental Research Funds for the Central Universities (201941001), the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) (No. 2018SDKJ0401-2), and Taishan Scholar Youth Expert Program in Shandong Province (tsqn201812021).

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