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Articles

Three new polyketides from the endophytic fungus Penicillium purpurogenum

, , , , , & show all
Pages 233-240 | Received 05 Oct 2019, Accepted 26 Nov 2019, Published online: 13 Dec 2019
 

Abstract

Three new polyketides including two benzophenone derivatives, penibenzones A and B (1 and 2), and a new phthalide derivative, penibenzone C (3), along with six known compounds, were isolated from the solid-substrate cultures of the endophytic fungus Penicillium purpurogenum IMM003. Their structures were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for inhibitory activity against pancreatic lipase, but none of them displayed activity.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NNSFC; nos. 81803397 and 81522050), the Science and Technology program of Qinghai (Grant No. 2018-ZJ-739), the Drug Innovation Major Project (Grant Nos. 2018ZX09711001-001, and 2018ZX09711001-008), the Special Research Fund for Central Universities, Peking Union Medical College (Grant No. 3332018088) and the Innovation Platform Construction Project of Qinghai Province (Grant No. 2017-ZJ-Y19).

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