Leucandioxoles A and B, two 1,3-benzodioxole derivatives from the South China Sea sponge Leucandra sp.

Abstract

Two new 1,3-benzodioxole derivatives, leucandioxoles A and B (1–2), together with two known related compounds (3–4), have been isolated from the South China Sea sponge Leucandra sp. The structures of all compounds were clearly elucidated on the basis of spectroscopic analyses and compared with the literatures. The cytotoxicity against A549, Hep G2, MDA-MB-231, and HeLa cell lines of 1–4 were evaluated. Only compound 1 exhibited moderate activity against MDA-MB-231 cells with the IC₅₀ value of 7.98 ± 0.74 μM.

Graphical Abstract

Keywords:

• Leucandra sp.
• benzodioxole derivatives
• cytotoxicity

Disclosure statement

The authors declared that they have no conflicts of interest to this work.

Additional information

Funding

This research was financially supported by the National Key Research and Development Program of China (No. 2018YFC0310900), PhD research development program of Shanghai Ocean University (No. A2-0203-00-100318), and the International Postdoctoral Exchange Fellowship Program (No. 20170092).