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Abstract
A couple of new cycloheximide epimers, 13(α)-acetoxy-anhydroisoheximide (1) and 13(β)-acetoxy-anhydroisoheximide (2), together with six known compounds (3–8), were obtained from the cultures of Streptomyces sp. YG7. The structures were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR, as well as HRESIMS, and by comparison with the literature. The X-ray crystal analysis of 1 further confirmed the structure. All the compounds were tested for antifungal activity. Compounds 1, 2 and 5–8 showed moderate Canidia albicans inhibitory activity, while 5 and 6 presented moderate Pyricularia oryzae inhibitory activity.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
The project was financially supported by the Natural Science Foundation of Hainan (2017CXTD020, 318MS011); Fund for Research Funds for Basic Research of the Chinese Academy of Tropical Agricultural Sciences (17-CXTD-15, 1630052019029).
