Benzoic acid derivatives from the root barks of Ailanthus altissima

Abstract

Two new benzoic acid derivatives (1–2), together with four known compounds (3–6) have been isolated from the n-BuOH soluble fraction of ethanolic extract from Ailanthus altissima. The gross structures of the new compounds were deduced by detailed spectroscopic analysis including HRESIMS and 1D/2D NMR spectroscopy. The stereochemistry of 1 was determined by modified Mosher’s method. All compounds were evaluated for their neuroprotective effects against H₂O₂-induced oxidative stress in human neuroblastoma SH-SY5Y cells and none of them displayed obvious neuroprotective activities.

Graphical Abstract

Keywords:

• Ailanthus altissima
• structure elucidation
• benzoic acid derivative

Disclosure statement

No potential conflicts of interest were reported by the authors.

Additional information

Funding

This work was financially supported by the National Nature Science Foundation (81872767) of China and Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006).