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Abstract
Two new phenolic glycosides (1-2), along with six existing compounds (3-8), were isolated from the ethanolic extract of Ilex pubescens roots, a traditional folk medicine. These structures were determined using HR-ESI-MS, IR, UV, and NMR (including 1 D, 2 D-NMR). The anti-inflammatory activities of three phenolic glycosides (1-3) were evaluated in the human HepG2 cell lines. The results showed that compound 3 could induce P-gp and BCRP expression through the Nrf2-mediated pathway.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by grants from the National Natural Science Foundation of China (81930114), the Science and Technology Project of Guangzhou City (201509010004) and Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine (2018B030322011).
